In [1, example C.1.2.8], a locale $Y$ (dense in another locale $X$) without any point is given. I fail to understand the point of such point-less locale - Why can't we identify those as the trivial locales, and what's so great about considering locales that have no points?
Anyway, here's the construction of $X$ and $Y$ (taken from [1]). Let $A$ be an uncountable nonempty set (e.g. $\mathbb{R}$) (equipped with the discrete topology), and let $X$ be the set of all functions $\mathbb{N} \to A$, equipped with the Tychonoff topology. For each $a \in A$, let $X_a$ be the subspace $\{f \in X \,|\, a \in im(f)\}$, and let $$ Y = \bigcap_{a\in A} X_{a}.$$ Now the point set $Y_p$ of $Y$ is empty because there is no onto map from $\mathbb{N}$ to $\mathbb{R}$.
In [2, section 5], Johnstone demonstrates why considering such locales could be useful. The main argument is that topoi are nice things to consider. However, at the point of writing, the (external) applications of topos theory seem lacking. Hopefully the situation has changed in mathematics in recent years. Thus the second question: How does the consideration of pointless locales help topos theory, and how does that in turn applies (externally) to mathematics?
Reference
[1] Sketches of an Elephant: A Topos Theory Compendium [Peter T. Johnstone]
[2] The point of pointless topology-[Peter T. Johnstone]