It will come from a compatibility between different ways of composing interchangers.
(I'm going to use = to mean iso/homotopy in a HoTT-like way throughout, for ease of notation. I will also confuse proofs and homotopies throughout.)
To get a better intuition, let's first think about the case of higher groupoids. As a warmup let's think about the braided case first. So there we have a homotopy 3-type which is 1-connected and we want to understand why there's a braiding on 2-loops. (Note that universally it's enough to just do this for the sphere $S^2$, so secretly we're trying to understand $\pi_3(S^2)$.) But, as you know, this is just the usual Eckmann-Hilton argument where we just braid the maps around each other. Translating this into compositions turns into the interchange law because the first half of the argument is:
$$x \circ_1 y = (x \circ_2 1) \circ_1 (1 \circ_2 y) = (x \circ_1 1) \circ_2 (1 \circ_1 y) = x \circ_2 y.$$
Note carefully that there are actually two proofs of Eckmann-Hilton: one where you rotate clockwise and one where you rotate counterclockwise. These proofs are different and they correspond to the two generators of $\pi_3(S^2) = \mathbb{Z}$. It is the fact that these two proofs of Eckmann-Hilton are different that makes these categories braided and not symmetric.
Alright, now let's move up one dimension higher. Now we're looking at 2-connected 4-groupoids. Now the algebraic topology question is the well-known fact that the generator of $\pi_3(S^2) = \mathbb{Z}$ has only order 2 when you stabilize it to put it in $\pi_4(S^3)$. Where does this come from? Well, it's clearly the same thing as asking why the two proofs of Eckmann-Hilton become the same when applied to 3-loops. Here the topological intuition is clear: take your clockwise proof and rotate it around the x-axis until it comes back into the plane becoming the counterclockwise proof.
Let's think about this in more detail. You can think of Eckmann-Hilton as taking place on a big square made up of four little squares with two tiles labelled x and y and the blanks labelled by identities and then sliding them around. Now we're looking in 3-dimensions at cubes and we want to slide one proof into the other by moving into the third dimension.
So we start with the proof:
$$x \circ_1 y = (x \circ_2 1) \circ_1 (1 \circ_2 y) = (x \circ_1 1) \circ_2 (1 \circ_1 y) = x \circ_2 y = \ldots = y \circ_1 x.$$
Next we need to introduce a third dimension to give ourselves more room to work. So maybe:
$$x \circ_1 y = (x \circ_2 1) \circ_1 (1 \circ_2 y) = (x \circ_1 1) \circ_2 (1 \circ_1 y) = ((x \circ_1 1) \circ_2 (1 \circ_1 y)) \circ_3 ((1 \circ_1 1) \circ_2 (1 \circ_1 1)) = \ldots$$
Then one gradually moves the clockwise proof around into the third dimension (so the interesting part is in the $\circ_2$ $\circ_3$ plane instead of the $\circ_1$ $\circ_2$ plane) and then back into the plane until it becomes the counterclockwise proof. I'm not going to write down the rest of this proof because it would take a while to get it entirely right and it would be hard to fit nicely on the screen anyway. But I'm confident that given a couple days I could write such a proof in Agda, and hopefully the idea is clear.
Just like the key lemma in proving Eckmann-Hilton is the interchange law, in order to prove this result we're going to need a higher interchanger relating the three compositions and their pairwise interchangers. Once you have such a higher interchanger the above proof should work for any doubly monoidal 4-category without groupoid-ness appearing anywhere.